Chenglong Li, Ph.D., an assistant professor in the College of Pharmacy at The Ohio State University, is using computational chemistry to help develop a genetically targeted drug that could surpass current approaches to treating a type of aggressive brain tumor called glioblastoma multiforme (GBM).
Alzheimer’s disease is the most common human neurodegenerative disorder, affecting as many as 5.1 million people in America alone. Alzheimer’s leads to progressive and irreversible memory loss, disability and, eventually, death through a complex series of events that take place in the brain over a period of many years.
Recently, large-scale sequencing projects have described the complete DNA blueprints for humans, the mouse and other organisms. This work highlighted the surprising fact that almost half of all mammalian DNA genomes is made up of mobile genetic elements called retrotransposons.
Follicular Lymphoma (FL) is one of the most common forms of non-Hodgkin Lymphoma occurring in the United States. FL is a slow-growing cancer of the human lymph system that usually spreads into the blood, bone marrow and, eventually, internal organs.
The Center for Surveillance Research (CSR), a National Science Foundation Industry/ University Cooperative Research Center, is a collaborative effort by academia, government and industry to conduct pre-competitive research and student training.
Scientific computing is credited for many of the technological breakthroughs of our generation and is used in many fields, ranging from drug discovery and aerospace to weather prediction and seismic analysis. Scientific computation often deals with very large amounts of data, and its algorithms need to compute results from mathematical models.
Scientists at The Ohio State University (OSU) are working to develop a drug that will regenerate a critical enzyme that “ages” after a person is exposed to deadly chemical warfare agents.
left: In a simulation created at the Ohio Supercomputer Center by Bowling Green's Massimo Olivucci, a short fragment of the long retinal chromophore backbone of Anabaena Sensory Rhodopsin undergoes a complete clockwise rotation powered by the energy carried by two photons.
Of all the American school children receiving special education services, the largest number suffer from learning language impairments, including a subset of children that have language as their only deficit. Specifically Language Impaired (SLI) children have weakened language ability but otherwise possess normal hearing, education and intelligence.
A group of enzymes implicated in a wide range of human diseases are important targets for anti-cancer therapies and the targets of a study by a molecular biologist to more fully understand the enzymes by helping to better define the group's family tree.