Biological Sciences

Biological Sciences icon

Ohio’s bioscience researchers are leveraging the resources of the Ohio Supercomputer Center to gather and analyze massive amounts of genetic, molecular and environmental data to better understand human physiology, individualize diagnoses and treat diseases.

Combating Nerve Agents

computational chemistry image

At the Ohio State Center for Catalytic Bioscavenger Medical Defense Research II, chemists Thomas J. Magliery and Christopher M. Hadad lead a team that employs sophisticated methods of protein engineering, high-throughput screening and computational chemistry.

Multi-scale Loading

A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads – virtual models that someday can be used tounderstand damage caused by the aging process or by debilitating diseases, such as osteoarthritis.

Low-light Detection

Human sight depends on an organized choreography of the retina with its cone and rods cells, the optic nerve, the brain’s visual cortex and light – be it a sunny day or a dark, star-studded night.

Remarkably, in extremely poor illumination conditions, the retina can still perceive intensities corresponding to only a few photons. Rod rhodopsins enable this high sensitivity.

Biomedical Visualization

Researchers at The Ohio State University’s Center for Clinical and Translational Science (CCTS) are using sophisticated scanners and powerful supercomputers to study how vitamin E can be used to reduce the extent of brain injury suffered by stroke patients.

Genetic Architecture

“When two genes interact to cause a clinically important phenotype, we can leverage genotypic information at one of the loci in order to improve our ability to detect the other,” said Veronica Vieland, Ph.D., vice president for computational research and director, Battelle Center for Mathematical Medicine.

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