Biological Sciences

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Ohio’s bioscience researchers are leveraging the resources of the Ohio Supercomputer Center to gather and analyze massive amounts of genetic, molecular and environmental data to better understand human physiology, individualize diagnoses and treat diseases.

Tricuspid Valves

Illustration from Amini's research

Tricuspid valve surgery is a common heart valve procedure in the United States, but it is one with poor long-term outcomes. In fact, studies show that up to 45 percent of those who receive tricuspid valve surgery suffer a recurrence of problems, in some cases as early seven years after surgery. In one-third of the cases, a second operation is required.

Lung Microbe

For patients facing chronic lung disease, the third leading cause of death in the U.S., the ultimate end-stage treatment is a lung transplant. Unfortunately, the survival rate for lung transplant patients is lower than that of other organ transplants due to infections and tissue rejection.

Cancer Research

In the Department of Genetics at Case Western Reserve University, Thomas LaFramboise, Ph.D., and his research team are discovering which genetic mutations determine a person’s susceptibility to developing leukemia.

RNA Signaling

The rise of antibiotic resistance among common infectious bacteria is a worrisome health threat that has many scientists looking for a solution. Jennifer Hines, Ph.D., professor of chemistry and biochemistry at Ohio University, is one of the few looking to ribonucleic acid (RNA) structures for new drug discovery.

Estrogen Receptors

A critical first step oncologists must take after finding a patient has breast cancer is to look for overexpressed hormone receptors in the cancer cells. This determines the type of therapy that will be used to most effectively combat the disease.

Botanical Alternatives

Sometimes numbers can be startling.

For instance, natural rubber is used in 50,000 commercial products, including 400 medical devices, because of its unique properties with regard to resilience, elasticity, abrasion and impact resistance, efficient heat dispersion and malleability at cold temperatures. It’s a critical raw material that developed countries simply can’t live without.

Hearing Loss

The difference between hearing and a lifetime of silence sometimes lies in the integrity of tiny inner ear proteins. Before Marcos Sotomayor, Ph.D., began studying these proteins, very little was known about hearing at the molecular level.

Bioinformatics Tools

In less than 10 years, the way genetic data has been collected has sped up in a major way. Previously, collecting data from a species was done one gene at a time, on an individual-by-individual basis, but new sequencing technologies allow researchers to process hundreds of thousands of genes at a time.

Metagenomic Data

The oldest forms of life on Earth, bacteria and archaea, have managed to evolve and adapt to Earth’s changing environment over billions of years. As a result, bacteria and archaea could hold the answers to the persistence of complex life.

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