HOMER (Hypergeometric Optimization of Motif EnRichment) is a suite of tools for Motif Discovery and ChIP-Seq analysis. It is a collection of command line programs for unix-style operating systems written in mostly perl and c++. Homer was primarily written as a de novo motif discovery algorithm that is well suited for finding 8-12 bp motifs in large scale genomics data.

Availability and Restrictions


The following versions of HOMER are available on OSC clusters:

Version owens
4.8 X*
* Current default version

You can use  module spider homer to view available modules for a given machine. Feel free to contact OSC Help if you need other versions for your work.


HOMER is available to all OSC users without restriction.

Publisher/Vendor/Repository and License Type

Christopher Benner, Open source


Usage on Owens


To configure your environment for use of HOMER, run the following command: module load homer. The default version will be loaded. To select a particular HOMER version, use module load homer/version. For example, use module load homer/4.8 to load HOMER 4.8.

Further Reading

Fields of Science: